Warning: If you have not played any of these games, some of the villains may come as somewhat of a spoiler.
1. The Hero from the Fable series.
Reason: The awesome customization that comes from the gamer's choice.
Reason: He makes a promise to a friend, and sticks to it..no matter the cost.
Reason: He keeps his homies at heart and doesn't let anybody f**k with him.
Reason: He was put in charge of completing a HUGE task, and pulled it off without flaw.
1. Seymour Guado from Final Fantasy 10.
Reason: He was a sadistic being set on destruction and power. Plus his haircut scared me.
Reason: He was just a straight up dick and ends up killing everybody's favorite character towards the end.
Reason: A being bent on destruction for no rhyme or reason, just wanted to see Albion burn.
Reason: He was an evil sith lord who (again like most baddies) is bent on power and domination.
Well guys that was my top 5, please feel free to give me your top 5 heroes and villians of the 2000 decade in the comments. and if I get enough points from this I'll make another list.